Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
halophiles 添加于 2010-2-24 09:45
| 1510 次阅读 | 0 个评论
作 者
Li JWH, Vederas JC 摘 要
Historically, the majority of new drugs have been generated from natural products (secondary metabolites) and from compounds derived from natural products. During the past 15 years, pharmaceutical industry research into natural products has declined, in part because of an emphasis on high-throughput screening of synthetic libraries. Currently there is substantial decline in new drug approvals and impending loss of patent protection for important medicines. However, untapped biological resources, "smart screening" methods, robotic separation with structural analysis, metabolic engineering, and synthetic biology offer exciting technologies for new natural product drug discovery. Advances in rapid genetic sequencing, coupled with manipulation of biosynthetic pathways, may provide a vast resource for the future discovery of pharmaceutical agents.-
详细资料
- 关键词: METAGENOMICS; CHEMISTRY; LEADS; MICROBIOLOGY; DIVERSITY; CHANNELS; CULTURE; ENZYMES; BIOLOGY
- 文献种类:期刊
- 期刊名称: SCIENCE
- 期卷页: 2009年 第325卷 第5937期 161-165页
- 出版社: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
- 地址: 1. Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2 Canada
- ISBN: 0036-8075
标 签
评论( 人)
相关链接
DOI
浙公网安备 33010202000686号 ( 浙ICP备09035230号-1 )
