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Transcriptional regulation of hepatic stellate cells

kevinlin2009 添加于 2010-3-4 21:17 | 1751 次阅读 | 0 个评论

作者
Mann J, Mann DA
摘要
Hepatic stellate cell (HSC) activation is a process of cellular transdifferentiation in which, upon liver injury, the quiescent vitamin A storing perisinusoidal HSC is converted into a wound-healing myofibroblast and acquires potent pro-inflammatory and pro-fibrogenic activities. This remarkable phenotypic transformation is underpinned by changes in the expression of a vast number of genes. In this review we survey current knowledge of the transcription factors that either control HSC activation or which regulate specific fibrogenic functions of the activated HSC such as collagen expression, proliferation and resistance to apoptosis.
详细资料
- 关键词: Animals; Cell Differentiation/*genetics; Gene Therapy; Hepatocytes/*physiology/ultrastructure; Humans; Liver Cirrhosis/genetics/pathology; Liver Diseases/genetics/pathology; Transcription Factors
- 文献种类:期刊
- 期刊名称: Advanced Drug Delivery Reviews
- 期刊缩写: Adv Drug Deliv Rev
- 期卷页: 2009年第61卷第7-8期 497-512页
- 地址: Liver Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. jelena.mann@ncl.ac.uk
- ISBN: 0169-409X
- 备注:PMID:19393271
标签

HSC
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