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Ribosomal frameshifting: an emerging drug target for HIV

gong329 添加于 2010-3-21 15:22 | 1186 次阅读 | 0 个评论

作者
Gareiss PC, Miller BL
摘要
Combating HIV currently remains one of the key public health challenges. While immense effort has been invested in the development of HIV-targeted therapeutic agents, interfering with protein synthesis is a relatively unexplored area. HIV has an absolute requirement for a -1 ribosomal frameshift event during translation that constitutes a potentially attractive target for interfering with the viral life cycle. Research suggests that while a considerable amount of investigation is still required, targeting frameshifting in HIV with small molecules, peptides and oligonucleotides is feasible.
详细资料
- 关键词: Anti-HIV Agents/metabolism/*pharmacology; Frameshifting, Ribosomal/*drug effects; HIV Infections/genetics; HIV-1/genetics/metabolism; Humans; Oligonucleotides, Antisense/genetics/*pharmacology; Peptides/genetics/*pharmacology; Protein Biosynthesis/drug effects; RNA, Viral/genetics/metabolism; Ribosomes/*metabolism
- 文献种类:期刊
- 期刊名称: Current Opinion in Investigational Drugs (London, England : 2000)
- 期刊缩写: Curr Opin Investig Drugs
- 期卷页: 2009年第10卷第2期 121-128页
- 地址: University of Rochester, Department of Dermatology, Rochester, New York, NY 14642, USA
- ISBN: 1472-4472
- 备注:PMID:19197789
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