Experimental cerebral ischemia: the contribution of the Bethesda Group
lxg1983 添加于 2010-3-30 23:23
| 1035 次阅读 | 0 个评论
作 者
Kuroiwa T 摘 要
Igor Klatzo started his research on cerebral ischemia at the NIH in the 1960s. The mechanism that produces the blood-brain barrier change after ischemia was a focus of interest in Klatzo's experiments, which used larger mammals. Studies using Mongolian gerbils, started by U. Ito, resulted in several important findings, including observation of the maturation phenomenon in 1975. Using newly developed ischemia models, the mechanism of postischemic neuronal/tissue injury was extensively studied. The cumulative effect was observed after repetitive cerebral ischemia. The protective mechanism of cortical spreading depression after global ischemia was investigated. Projects including in vitro studies of human brain endothelial cells and mucosal tolerance to E-selectin were performed in the Stroke branch after Klatzo retired from the NIH. Klatzo published a biography of Cecil and Oskar Vogt after retirement. He passed away in May 2007 in Gaithersburg, Maryland a few months after he completed the first part of his autobiography.-
详细资料
- 关键词: Animals; Blood-Brain Barrier/physiopathology; Brain Edema/*history/*physiopathology/therapy; Brain Ischemia/pathology/*physiopathology/*therapy; Cortical Spreading Depression/physiology; History, 20th Century; History, 21st Century; Humans; National Institutes of Health (U.S.)/history; Research/history; United States
- 期刊名称: Acta Neurochirurgica. Supplement
- 期刊缩写: Acta Neurochir Suppl
- 期卷页: 2010年 第106卷 17-19页
- 地址: Laboratory of Clinical Medicine, Namegata District General Hospital, Namegata, Ibaraki, Japan. tkuroiwa-nsu@umin.ac.jp
- ISBN: 0065-1419
- 备注:PMID:19812914
-
评论( 人)
相关链接
DOI URL
浙公网安备 33010202000686号 ( 浙ICP备09035230号-1 )
