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Thermal Isomerization of Cannabinoid Analogues

lygqpg2005 添加于 2010-4-17 16:31 | 1674 次阅读 | 0 个评论

作者
Garcia A, Borchardt D, Chang C-EA, Marsella MJ
摘要
Thermal isomerization of CBC_an to THC_an [nonaromatic analogues of plant cannabinoids cannabichromene (CBC) and Δ¹-tetrahydrocannabinol (THC), respectively] is predicted in silico and demonstrated experimentally. Density functional theory calculations support a similar isomerization mechanism for the corresponding plant cannabinoids. Docking studies suggest that THC_an, although nonaromatic, has a CB₁ receptor binding affinity similar to that of natural THC.
详细资料
- 文献种类:期刊
- 期刊名称: Journal of the American Chemical Society
- 期刊缩写: J. Am. Chem. Soc.
- 期卷页: 2009年第131卷第46期 16640-16641页
- ISBN: 0002-7863
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