Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies
liuhflx 添加于 2010-4-19 10:30
| 1700 次阅读 | 0 个评论
作 者
Li J-T, Liao Z-X, Ping J, Xu D, Wang H 摘 要
Activation of hepatic stellate cells (HSCs) is the dominant event in liver fibrosis. The early events in the organization of HSC activation have been termed initiation. Initiation encompasses rapid changes in gene expression and phenotype that render the cells responsive to cytokines and other local stimuli. Cellular responses following initiation are termed perpetuation, which encompasses those cellular events that amplify the activated phenotype through enhanced growth factor expression and responsiveness. Multiple cells and cytokines play a part in the regulation of HSC activation. HSC activation consists of discrete phenotype responses, mainly proliferation, contractility, fibrogenesis, matrix degradation, chemotaxis and retinoid loss. Currently, antifibrotic therapeutic strategies include inhibition of HSC proliferation or stimulation of HSC apoptosis, downregulation of collagen production or promotion of its degradation, administration of cytokines, and infusion of mesenchymal stem cells. In this review, we summarize the latest advances in our understanding of the mechanisms of HSC activation and possible antifibrotic therapeutic strategies.-
详细资料
- 关键词: Animals; Apoptosis; Cell Proliferation; Chemotaxis; Cytokines/physiology; Hepatocytes/metabolism/*physiology; Humans; Liver Cirrhosis/*physiopathology/therapy
- 文献种类:期刊
- 期刊名称: Journal of Gastroenterology
- 期刊缩写: J Gastroenterol
- 期卷页: 2008年 第43卷 第6期 419-428页
- 地址: Department of Pharmacology, Basic Medical School of Wuhan University, Luojia Hill, Wuhan 430071, China
- ISBN: 0944-1174
标 签
评论( 人)
相关链接
DOI URL
浙公网安备 33010202000686号 ( 浙ICP备09035230号-1 )
