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Preliminary results of a skin prick test-based study of the prevalence and clinical impact of hypersensitivity to pollen panallergens (polcalcin and profilin)

zhangbaite 添加于 2010-4-20 16:22 | 1902 次阅读 | 0 个评论

作者
Asero R, Jimeno L, Barber D
摘要
BACKGROUND: Calcium-binding proteins (polcalcins) and profilin are cross-reacting panallergens that sensitize a minority of pollen-allergic patients. Their clinical relevance remains controversial. OBJECTIVE: To assess the clinical relevance of hypersensitivity to polcalcin and profilin detected by skin prick test (SPT) in a large group of pollen-allergic patients. METHODS: Two hundred pollen-allergic adults (101 men, 99 women; mean age 34 years) underwent SPT with 9 pollens present in the geographical area of the study. Hypersensitivity to panallergens was detected by SPT with date palm polcalcin and profilin. Allergy to birch and/or cypress, grass and/or pellitory, and ragweed and/or mugwort were associated with 3 symptomatic periods, respectively, late February to mid-May, late April to mid-July, and mid-August to late September. RESULTS: Sixteen (8%) patients reacted to date palm polcalcin; 7/7 (100%) corecognized the grass polcalcin Phl p 7 in vitro. Clinically, only 4 (25%) had symptoms in all 3 seasonal periods. Forty (20%) patients reacted to profilin; only 32 (80%) reacted to cypress, and 22 (55%) to pellitory. Only 4 (10%) patients had symptoms during all 3 seasonal periods. Six patients (3%) were cosensitized to both polcalcin and profilin. CONCLUSIONS: The clinical relevance of hypersensitivity to pollen panallergens is often limited; many allergic patients have symptoms only during the central period, suggesting primary grass sensitization. Profilin-allergic patients often do not corecognize pellitory and cypress pollen. In vivo component-resolved diagnosis of seasonal respiratory allergies is a promising approach that might lead to cost reduction and a faster definition of pollen-allergic cases.
详细资料
- 关键词: Adolescent; Adult; Aged; Allergens/*immunology; Calcium-Binding Proteins/*immunology; Child; Child, Preschool; Cross Reactions; Female; Humans; Male; Middle Aged; Prevalence; Rhinitis, Allergic, Seasonal/*epidemiology; Skin Tests
- 文献种类:期刊
- 期刊名称: Journal of Investigational Allergology & Clinical Immunology : Official Organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunologia
- 期刊缩写: J Investig Allergol Clin Immunol
- 期卷页: 2010年第20卷第1期 35-38页
- 地址: Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy. r.asero@libero.it
- ISBN: 1018-9068
- 备注:PMID:20232772
标签

Rhinitis, Allergic, Seasonal
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