Emergence of the GII4/2006b variant and recombinant noroviruses in China
王关中 添加于 2010-4-26 15:58
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作 者
Jin M, Xie H-ping, Duan Z-jun, Liu N, Zhang Q, Wu B-shan, Li H-ying, Cheng W-xia, Yang S-hua, Yu J-mei, Xu Z-qian, Cui S-xian, Zhu L, Tan M, Jiang X, Fang Z-yin 摘 要
Noroviruses are an important cause of acute gastroenteritis. Increasing data showed that the GII-4 strains are predominant worldwide and new GII-4 variants emerge every 1-2 years causing major epidemics. Surveillance of gastroenteritis in hospitalized children under 5 years of age in China is described. Among 1,110 specimens, 114 (10.3%) were positive for noroviruses, which was higher than adenoviruses (7.6%), astroviruses (3.5%), and sapoviruses (0.9%) and only lower than group A rotaviruses (40.6%). Thirty-eight of the 114 positive norovirus cases were co-infected with other enteric viruses. Five norovirus genotypes (GI-2, GI-4, GII-3, GII-4, and GII-14) were detected, with GII-4/2006b the most predominant type (64.9%). The reported recombinant of GII-3 capsid and GII-4 polymerase described previously was also detected frequently and a recombinant of GII-14 capsid and GII-6 polymerase was found for the first time. This study suggests that continual surveillance focusing on strain variation and dynamic change is important for understanding the epidemiology and development of a strategy for disease control and prevention. J. Med. Virol. 80:1997-2004, 2008. © 2008 Wiley-Liss, Inc.-
详细资料
- 文献种类:期刊
- 期刊名称: Journal of Medical Virology
- 期刊缩写: J. Med. Virol.
- 期卷页: 2008年 第80卷 第11期 1997-2004页
- ISBN: 0146-6615
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