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What is the true nature of the osteoblastic hematopoietic stem cell niche?

热1 dr.qinan 添加于 2009-7-18 18:51 | 1834 次阅读 | 0 个评论

作者
Askmyr M, Sims NA, Martin TJ, Purton LE
摘要
The recently revitalized interest in the regulation of hematopoietic stem cells (HSCs) by the bone marrow microenvironment has resulted in the identification of some important cell types that potentially form the HSC niche. The term 'osteoblast' has commonly been used to describe the endosteal elements of the HSC niche, but these cells are part of a larger family that functions in bone at different stages of differentiation. Given that there is much controversy as to what cell types have important roles in the HSC niche, this review offers an overview of the diverse osteoblastic cell types and discusses the current evidence regarding what roles they have in the HSC niche.
详细资料
- 文献种类:期刊
- 期刊名称: Trends in Endocrinology and Metabolism: TEM
- 期刊缩写: Trends Endocrinol Metab
- 期卷页: 2009年
- 地址: St Vincent's Institute, Fitzroy, Victoria, 3065, Australia
- ISBN: 1043-2760
- 备注:PMID:19595609
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