新科学想法 › 文献管理 › 浏览文献

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

yunwang 添加于 2009-7-20 08:58 | 1727 次阅读 | 0 个评论

作者
Li JWH, Vederas JC
摘要
Historically, the majority of new drugs have been generated from natural products (secondary metabolites) and from compounds derived from natural products. During the past 15 years, pharmaceutical industry research into natural products has declined, in part because of an emphasis on high-throughput screening of synthetic libraries. Currently there is substantial decline in new drug approvals and impending loss of patent protection for important medicines. However, untapped biological resources, "smart screening" methods, robotic separation with structural analysis, metabolic engineering, and synthetic biology offer exciting technologies for new natural product drug discovery. Advances in rapid genetic sequencing, coupled with manipulation of biosynthetic pathways, may provide a vast resource for the future discovery of pharmaceutical agents.
详细资料
- 关键词: METAGENOMICS; CHEMISTRY; LEADS; MICROBIOLOGY; DIVERSITY; CHANNELS; CULTURE; ENZYMES; BIOLOGY
- 文献种类:期刊
- 期刊名称: SCIENCE
- 期卷页: 2009年第325卷第5937期 161-165页
- 出版社: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
- 地址: 1. Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2 Canada
- ISBN: 0036-8075
相关链接 DOI

3 人收藏