维生素D3和姜黄素

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Vitamin D, Curcumin May Help Clear Amyloid Plaques Found In Alzheimer's Disease
维生素D3和姜黄素可能有助于清除阿尔茨海默病淀粉样蛋白斑块

http://www.sciencedaily.com/releases/2009/07/090715131558.htm

ScienceDaily (July 16, 2009) — UCLA scientists and colleagues from UC Riverside and the Human BioMolecular Research Institute have found that a form of vitamin D, together with a chemical found in turmeric spice called curcumin, may help stimulate the immune system to clear the brain of amyloid beta, which forms the plaques considered the hallmark of Alzheimer's disease.
每日科学7月16日新闻----加利福尼亚大学洛杉矶分校的科学家们发现维生素D3 ，和姜黄属植物中含有的姜黄素可能有助于刺激免疫系统清除脑部β淀粉样蛋白，众所周知，由β淀粉样蛋白形成的淀粉斑块是阿尔茨海默氏病的标志。

The early research findings, which appear in the July issue of the Journal of Alzheimer's Disease, may lead to new approaches in preventing and treating Alzheimer's by utilizing the property of vitamin D3 — a form of vitamin D — both alone and together with natural or synthetic curcumin to boost the immune system in protecting the brain against amyloid beta.
早期的研究结果刊登在7月的 阿尔茨海默病杂志上 对于阿尔茨海默氏症的预防和治疗，这将可能引导一种新疗法：通过维生素D3 （维生素D的一种），单独或与天然/合成的姜黄素类联用来刺激免疫系统，保护大脑免受β淀粉样蛋白的伤害。

Vitamin D3 is an essential nutrient for bone and immune system health; its main source is sunshine, and it is synthesized through the skin. Deficiencies may occur during winter months or in those who spend a lot of time indoors, such as Alzheimer's patients.
维生素D3对骨骼和免疫系统来说，是一个重要元素，主要来源是通过太阳光照，由皮肤合成。 在缺少阳光的冬季或户外活动少(如阿尔茨海默氏症患者)都有可能会缺乏维生素D3。

"We hope that vitamin D3 and curcumin, both naturally occurring nutrients, may offer new preventive and treatment possibilities for Alzheimer's disease," said Dr. Milan Fiala, study author and a researcher at the David Geffen School of Medicine at UCLA and the Veterans Affairs Greater Los Angeles Healthcare System.
“我们希望，维生素D3和姜黄素这两种天然成分能够提供阿尔茨海默氏病新的预防和治疗方法，Milan Fiala博士说，他是加州大学洛杉矶分校大卫格芬医学院和退伍军人事务部大洛杉矶医疗保健系统的一名研究者，同时也是MP生物医学公司顾问。

Using blood samples from nine Alzheimer's patients, one patient with mild cognitive impairment and three healthy control subjects, scientists isolated monocyte cells, which transform into macrophages that act as the immune system's clean-up crew, traveling through the brain and body and gobbling up waste products, including amyloid beta. Researchers incubated the macrophages with amyloid beta, vitamin D3 and natural or synthetic curcumin.
对9名阿尔茨海默氏症患者， 1名轻度认知障碍患者和三名健康的对照者分别采集血液样本，从中分离出单核细胞，这些单核细胞可转化为巨噬细胞，成为免疫系统的清理大军，在身体各部分吞噬人体的废物，包括β淀粉样蛋白。研究人员在培养巨噬细胞时分别加入了β淀粉样蛋白，维生素D3和天然/合成的姜黄素类化合物。

The synthetic curcuminoid compounds were developed in the laboratory of John Cashman at the Human BioMolecular Research Institute, a nonprofit institute dedicated to research on diseases of the human brain.Researchers found that naturally occurring curcumin was not readily absorbed, that it tended to break down quickly before it could be utilized and that its potency level was low, making it less effective than the new synthetic curcuminoids.
合成姜黄素类化合物工作是由人类生物研究所John Cashman实验室完成，这是一个非营利性研究所，致力于人类脑部疾病的研究。研究人员发现天然的姜黄素不容易被吸收，往往在被利用之前就已经降解因此使得药效降低，效果低于新合成的姜黄素类化合物 。

"We think some of the novel synthetic compounds will get around the shortcomings of curcumin and improve the therapeutic efficacy," Cashman said.
我们认为一些新合成的化合物可能能够克服姜黄素的缺点，提高治疗效果，Cashman说。

The team discovered that curcuminoids enhanced the surface binding of amyloid beta to macrophages and that vitamin D strongly stimulated the uptake and absorption of amyloid beta in macrophages in a majority of patients.
研究发现， 对于大多数病人，姜黄素类衍生物提高了β淀粉样蛋白与巨噬细胞的表面结合，而维生素D强烈刺激了巨噬细胞内β淀粉样蛋白的摄取和吸收。

Previous research by the team demonstrated that the immune genes MGAT III and TLR-3 are associated with the immune system's ability to better ingest amyloid beta. In this earlier work, Fiala noted, it was shown that there are two types of Alzheimer's patients: Type 1 patients, who respond positively to curcuminoids, and Type II patients, who do not.
该小组以往的研究表明免疫基因MGAT -III和TLR - 3都与免疫系统更好地摄取β淀粉样蛋白有关。Fiala指出，早前的研究结果发现阿尔茨海默氏症患者有两种类型： I型患者对类姜黄素化合物有着积极反应而II型患者没有反应。

"Since vitamin D and curcumin work differently with the immune system, we may find that a combination of the two or each used alone may be more effective — depending on the individual patient," he said.
“由于维生素D和姜黄素对免疫系统的作用机制不同，有可能会发现，两者组合使用或单独使用都可能效果更好的情况，这要看不同的病人了”他说。

Fiala noted that this is early laboratory research and that no dosage of vitamin D or curcumin can be recommended at this point. Larger vitamin D and curcumin studies with more patients are planned.
Fiala指出，这仍是早期的实验室研究，在现阶段尚没有建议剂量的研究。针对更多病人的较大剂量的维生素D和姜黄素研究正在计划中。

The study was funded by the Human BioMolecular Research Institute, the Alzheimer's Association and MP Biomedicals LLC, a global life sciences and diagnostics company dedicated to Alzheimer's disease research.
该研究由人类生物分子研究所，阿尔茨海默症协会和MP生物医学公司（一家全球性生命科学和诊断试剂公司，致力于老年痴呆症的研究）资助。