Some Lessons from My Work on the Biochemistry of the Ubiquitin System

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Avram Hershko:
     When I was asked to write a Reflections article for the Journal of Biological Chemistry, I initially hesitated, mainly because I had already written several papers on the story of the discovery of the ubiquitin system (1–4). On second thought, however, it seemed worthwhile to write about it from a different aspect, about what can be learned from this story. I hope that some of the lessons may be of help to students or young investigators in their future work.