BJUI：年轻时性生活活跃男性易患前列腺癌

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英国诺丁汉大学对800名男性进行的一项调查显示，那些在二三十岁时，性生活比较活跃的男性，患上前列腺癌的几率更高。

研究是针对400名患有前列腺癌的病人，以及409名没有患病的男性进行的。

参与调查的人必须透露，他们自发育期以来的性事有多频繁、有几个性伴侣，以及是否曾患有性病等。

进行这项研究的科学家在《英国国际泌尿学期刊》（BJUI）里表示，性欲高的男性，代表着他们的男性贺尔蒙多。而很多研究也似乎透露着，男性贺尔蒙多，很有可能是引发前列腺癌的重要因素之一。

在患前列腺癌的男性中，有40%在20多岁的时候，每个月有超过20次的性活动(如：手淫和□)，而只有32%的没有患癌的男性，有同样活跃的性生活。

此外，患前列腺癌的男性当中，有将近40%有6名以上的性伴侣，相比之下，没有患癌的男性，只有少过三分之一有六名以上的性伴侣的。

研究小组的组长表示，他们把注意力放在年轻男性身上，而且也在研究包括手淫在内的性活动。

英国前列腺癌慈善团体总裁说，由于调查需要这些男性回想二三十年前的事，因此所提供的资料未必准确。（生物谷Bioon.com）

生物谷推荐原始出处：

BJUI，doi: 10.1111/j.1464-410X.2008.08030.x，Polyxeni Dimitropoulou，Kenneth R. Muir

Sexual activity and prostate cancer risk in men diagnosed at a younger age

Polyxeni Dimitropoulou, Artitaya Lophatananon*, Douglas Easton**, Richard Pocock, David P. Dearnaley , Michelle Guy, Steven Edwards, Lynne O'Brien, Amanda Hall, Rosemary Wilkinson, The UK Genetic Prostate Cancer Study Collaborators, British Association of Urological Surgeons Section of Oncology, Rosalind Eeles ? and Kenneth R. Muir

University of Nottingham Medical School, Queens Medical Centre, Nottingham, UK, *The Chulabhorn Cancer Hospital, Bangkok, Thailand, **Department of Public Health and Primary Care, CR-UK Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, ? Royal Devon and Exeter NHS Trust, Exeter, and ? Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, Surrey UK

ABSTRACT

To examine, in a case-control study, the association between the frequency of sexual activity (intercourse, masturbation, overall) and prostate cancer risk in younger men diagnosed at ≤60 years old.

PATIENTS, SUBJECTS AND METHODS

In all, 431 prostate cancer cases and 409 controls participated and provided information on their sexual activity. In particular, the frequencies of intercourse and masturbation during the participants' different age decades (20s, 30s, 40s, 50s) were collected.

RESULTS

Whereas frequent overall sexual activity in younger life (20s) increased the disease risk, it appeared to be protective against the disease when older (50s). Alone, frequent masturbation activity was a marker for increased risk in the 20s and 30s but appeared to be associated with a decreased risk in the 50s, while intercourse activity alone was not associated with the disease.

CONCLUSION

These findings could imply different mechanisms by which sexual activity is involved in the aetiology of prostate cancer at different ages. Alternatively, there is a possibility of reverse causation in explaining part of the protective effect seen for men in their 50s.