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Peter J. Francis, Associate Professor in Casey Eye Institute. 他的团队参与了FDA批准的第二项人胚胎干细胞一期和二期临床试验，用于治疗遗传性眼病。 4.21～4.24，Peter将在杭州与浙大医学院附属第一医院眼科的遗传性眼病中心进行学术交流。 4.22下午Peter在浙一有lecture，欢迎参加。
Peter近3年来的文章： Klein ML, Francis PJ, Rosner B, Reynolds R, Hamon S, Ott J, Seddon J.
CFH and LOC387715/ARMS2 Genotypes and Treatment with Antioxidants and Zinc for Age-Related Macular Degeneration.
Ophthalmology 2008;115(6):1019-25 Francis PJ, Zhang H, DeWan A, Hoh J, Klein M. Joint effects of the HTRA1, LOC387715/ARMS2 and CFH genes on AMD in a Caucasian population. Molecular Vision 2008;14:1395-400 Sharma SM, Watzke RC, Weleber RG, Smith JR, Francis PJ. AZOOR and Pars Planitis : a new association? British Journal of Ophthalmology 2008;92(4):583-4 Francis PJ, Appukuttan B, Simmons E, Landauer N, Stoddard J, Hamon S, Ott J, Ferguson B, Klein ML, Stout JT, Neuringer M. Rhesus Monkeys and Humans Share Common Susceptibility Genes for Age-Related Macular Disease. Human Molecular Genetics 2008;17(17):2673-80. PMC2733804 Yang Z*, Stratton C*, Francis PJ*, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J, Pearson E, Patel S, Kaminoh Y, Watkins S, Luo L, Zabriskie NA, Bernstein PS, Cho W, Schwager A, Hinton DR, Klein ML, Hamon SC, Simmons E, Yu B, Campochiaro B, Sunness JS, Campochiaro P, Jorde L, Parmigiani G, Zack DJ, Katsanis N, Ambati J, Zhang K. Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration. New England Journal of Medicine 2008;359(14):1456-63 *these authors contributed equally Choroideremia: analysis of the retina from a female symptomatic carrier. Ophthalmic Genetics 2008;29(3):99-110 Polymorphisms in C2, CFB and C3 are associated with progression to Advanced Age-Related Macular Degeneration associated with visual loss. Journal of Medical Genetics 2009;46(5):300-7 Francis PJ, Wang S, Zhang Y, Brown A, Hwang T, McFarland TJ, Jeffrey BG, Lu B, Wright L, Appukuttan B, Wilson DJ, Stout JT, Neuringer M, Gamm DM, Lund RD. Subretinal Transplantation of Forebrain Progenitor Cells in Non-human Primates: Survival and Intact Retinal Function. Investigative Ophthalmology and Visual Science. 2009 Jul;50(7):3425-31. NIHMSID 171589 SanGiovanni JP, Arking DE, Iyengar SK, Elashoff M, Clemons TE, Reed GF, Henning AK, Sivkumaran TA, Xu X, DeWan A, Agrón E, Rochtchina E Sue CM, Wang JJ, Mitchell P, Hoh J, Francis PJ, Klein ML, Chew EY, Chakravarti A. Mitochondrial DNA Variants of Respiratory Complex 1 that Uniquely Characterize Haplogroup T2 are Associated with Increased Risk of Advanced AMD PLoSONE 2009;4(5):e5508 PMC2677106 Coccia M, Brooks SP, Webb TR, Christodoulou K, Wozniak IO, Murday V, Balicki M, Yee HA, Wangensteen T, Riise R, Saggar AK, Park S-M, Kanuga N, Francis PJ, Maher ER, Moore AT, Russell-Eggitt IM, Hardcastle AJ. X-linked Cataract and Nance-Horan Syndrome are Allelic Disorders Human Molecular Genetics 2009; 18(14):2643-55. PMC2701339 Sohn EH, Francis PJ, Duncan JL, Weleber RG, Saperstein DA, Farrell DF, Stone EM. Phenotypic variability due to a novel Glu292Lys variation in exon 8 of the BEST1 gene causing best macular dystrophy. Arch Ophthalmol. 2009 Jul;127(7):913-20. PMC2711525 Lu B, Malcuit C, Wang S, Girman S, Francis P, Lemieux L, Lanza R, Lund R. Long-Term Safety and Function of RPE from Human Embryonic Stem Cells in Preclinical Models of Macular Degeneration. Stem Cells. 2009;27(9):2126-2135. Jones J, Francis PJ. Topical non-steroidal therapy for macular disease. Expert Opinion in Pharmacotherapy. 2009;10(14):2379-85. Francis PJ. The etiology of age-related macular degeneration Ophthalmology International, 2010;5:12-15 Klein ML,
Ferris FL III, Francis PJ, Lindblad AS, Chew EY, Hamon SC, Ott J.
Progression of Geographic Atrophy and Genotype in Age-Related Macular Degeneration. Ophthalmology 2010;117(8):1554-9 Lu B, Wang S, Francis PJ, Li T, Gamm DM, Capowski EE, Lund RD. Cell Transplantation to Arrest Early Changes in an USH2A Animal Model. Invest Ophthalmol Vis Sci. 2009;51(4):2269-76 Chen W, Stambolian D, Edwards AO, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A. Genetic Variants near TIMP3 and HDL-Associated Loci Influence Susceptibility to Age-Related Macular Degeneration. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7401-6 Wang RK, An L, Francis P, Wilson DJ. Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiogathy Opt Lett. 2010 May 1;35(9):1467-9 Chan-Kai BT, Yeh S, Weleber RG, Francis PJ, Adamus G, Witherspoon SR, Lauer AK. Electroretinographic findings in transplant chorioretinopathy Clinical Ophthalmology 2010:4 1–7 Yeh S, Hwang TS, Weleber RG, Watzke RC, Francis PJ. Acute macular outer retinopathy (AMOR): a reappraisal of acute macular neuroretinopathy (AMNR) using multimodality diagnostic testing Archives of Ophthalmology 2010 (in press) Michaelides M, Stover NB, Francis PJ, Weleber RG. Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy. Arch Ophthalmol. 2011 Jan;129(1):30-9 Kopplin LJ, Igo RP Jr, Wang Y, Sivakumaran TA, Hagstrom SA, Peachey NS, Francis PJ, Klein ML, SanGiovanni JP, Chew EY, Pauer GJ, Sturgill GM, Joshi T, Tian L, Xi Q, Henning AK, Lee KE, Klein R, Klein BE, Iyengar SK. Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. Genes Immun. 2010 Dec;11(8):609-21
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