第四军医大学金岩课题组一项新的研究提示成人骨髓干细胞可以用于构建人造皮肤。这些发现标志着创伤愈合的一项进展，而且可能用于开创一种器官重建的方法。这项研究发表在了《人工器官》（Artificial Organs）杂志上。该杂志是国际人工器官联合会（IFAO）、国际人工器官联合大学（INFA）和国际旋转式血泵学会（ISRBP）的官方刊物。
为了调查用组织工程和骨髓干细胞修复烧伤的可行性，该研究用猪的皮肤建立了一种烧伤模型，已知它在解剖和生理学上类似于人类皮肤。
科学家利用工程技术和生物医学理论方法，用自然材料和骨髓干细胞制造出了人工皮肤。一旦人工皮肤附着在患者身上，而真皮层开始再生，干细胞就会分化成皮肤细胞。这些细胞会自我更新，而且提高了创伤愈合疗法的愈合质量。当移植给烧伤患者后，这种经过改造的含有干细胞的皮肤表现出了更好的愈合效果，更少的创伤收缩和更好的血管发育。
皮肤是人体最大的器官，它保护人体不受疾病和物理损伤的伤害，而且可以帮助调节体温。当皮肤被疾病或烧伤严重损伤后，人体常常无法足够迅速地行动起来以修复它们。烧伤患者可能死于感染和血浆损失。最初开发皮肤移植术是为了防止这类后果。
“我们希望这种所谓的‘工程结构组织’将有朝一日用合适的材料和干细胞取代目前用于替换受损关节和骨骼的塑料和金属的假体，”该研究的第一作者、第四军医大学的金岩说。（生物谷Bioon.com）
生物谷推荐原始出处：
Artificial Organs Volume 32 Issue 12, Pages 925 - 931 DOI：0.1111/j.1525-1594.2008.00654.x
Tissue-Engineered Skin Containing Mesenchymal Stem Cells Improves Burn Wounds
Peng Liu, Zhihong Deng, Shufang Han, Tao Liu, Ning Wen, Wei Lu, Xianhui Geng, Sha Huang, and Yan Jin
*Department of Oral Histology and Pathology, School of Stomatology; ?Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi'an, Shaanxi; ?General Hospital of Jinan Military Region, PLA, Jinan, Shandong; §Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi; and ?Department of Stomatology, Beijing 301 General Hospital of PLA, Beijing, China
ABSTRACT
There is increasing evidence showing that adult stem cells are useful for tissue regeneration. Bone marrow mesenchymal stem cells (MSCs) are self-renewing and are potent in differentiating into multiple cells and tissues. To investigate the practicability of repairing burn wounds with tissue-engineered (TE) skin combined with bone MSCs, we established a burn wound model in the porcine skin. With a controlling temperature and time of the burning device to obtain different degrees of burn wounds, a deep dermal partial thickness burn was introduced to the porcine skin using a heated-brass contact injury at 100°C for 20 s. Collagen-GAG scaffolds were utilized as the matrix; MSCs separated from pigs were seeded on them to form the skin equivalent. When grafted to the burn wounds, the TE skin containing MSCs showed better healing and keratinization, less wound contraction, and more vascularization. Grafts proliferated well and contributed to the neo-tissues. These data suggest that TE skin containing MSCs in a burn defect can accelerate wound healing and receive satisfactory effects.
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发表于 2009-2-6 07:59:14
