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骨质疏松-睾酮与骨质疏松 20130921

热度 1已有 4543 次阅读 2013-9-21 09:33 |个人分类:personal| 骨质疏松, 睾酮

睾酮缺乏与男性骨质疏松的关系研究

The Relationship between Testosterone Deficiency and Men's Health

Testosterone is important in the physiology of various organs and tissues. The serum testosterone concentration gradually declines as one of the processes of aging. Thus, the concept of late-onset hypogonadism has gained increasing attention in the last few years. Reported symptoms of late-onset hypogonadism are easily recognized and include diminished sexual desire and erectile quality, particularly in nocturnal erections, changes in mood with concomitant decreases in intellectual activity and spatial orientation, fatigue, depression and anger, a decrease in lean body mass with associated decreases in muscle volume and strength, a decrease in body hair and skin alterations, and decreased bone mineral density resulting in osteoporosis. Among these various symptoms, sexual dysfunction has been the most common and necessary to treat in the field of urology. It is well known that a low serum testosterone level is associated with erectile dysfunction and hypoactive sexual libido and that testosterone replacement treatment can improve these symptoms in patients with hypogonadism. Recently, in addition to sexual dysfunction, a close relationship between metabolic syndrome, characterized by central obesity, insulin resistance, dyslipidemia, and hypertension, and late-onset hypogonadism has been highlighted by several epidemiologic studies. Several randomized control trials have shown that testosterone replacement treatment significantly decreases insulin resistance in addition to its advantage for obesity. Furthermore, metabolic syndrome is one of the major risk factors for cardiovascular disease, and a low serum testosterone level is closely related to the development of atherosclerosis. Presently, it is speculated that a low serum testosterone level may increase the risk for cardiovascular disease. Thus, testosterone is a key molecule in men's health, especially that of elderly men.

睾酮在很多组织和器官中发挥重要的生理功能。随着年龄的增长，血清中睾酮水平逐渐下降。因此，在老年人血清中低睾酮水平引起了重视，低睾酮者可表现为性欲下降，勃起功能障碍，空间定位下降，疲劳，抑郁，易激，肌肉含量下降，体毛改变，骨量改变。在这些症状中，男科学常针对性欲改变进行诊治，可以通过睾酮替代治疗改善症状。目前发现，除了性功能改变，血清睾酮水平与代谢综合症相关，如向心性肥胖，胰岛素抵抗，血脂异常，高血压。许多随机对照研究表明，睾酮替代治疗可以显著改善胰岛素抵抗，改善肥胖。此外，血清低睾酮水平与血管硬化相关，低血清睾酮水平可能是一个心血管疾病的危险因素。因此，睾酮在男性，尤其是老年男性中，具有非常重要的作用。