Genetic Signatures of Exceptional Longevity in Humans
Dr.Moth 添加于 2010-7-3 23:22
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作 者
Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT 摘 要
Healthy aging is thought to reflect the combined influence of environmental factors (lifestyle choices) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity (EL) in 1055 centenarians and 1267 controls. Using these data, we built a genetic model that includes 150 single-nucleotide polymorphisms (SNPs) and found that it could predict EL with 77% accuracy in an independent set of centenarians and controls. Further in silico analysis revealed that 90% of centenarians can be grouped into 19 clusters characterized by different combinations of SNP genotypes-or genetic signatures-of varying predictive value. The different signatures, which attest to the genetic complexity of EL, correlated with differences in the prevalence and age of onset of age-associated diseases (e.g., dementia, hypertension, and cardiovascular disease) and may help dissect this complex phenotype into subphenotypes of healthy aging.-
详细资料
- 文献种类: Journal Article
- 期刊名称: Science (New York, N.Y.)
- 期刊缩写: Science
- 期卷页: 2010年
- 地址: Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
- ISBN: 0036-8075
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学科领域 生物医药 » 生物学
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