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Mitomycin: effects on laryngeal and tracheal stenosis, benefits, and complications

Butterfly 添加于 2010-7-13 09:42 | 2122 次阅读 | 0 个评论

作者
Rahbar R, Shapshay SM, Healy GB
摘要
The management of laryngeal and tracheal stenosis continues to challenge us, despite advances in surgical techniques and better understanding of the wound healing process. Injury to the airway mucosa is the inciting event, regardless of the cause of the stenosis. Mitomycin-C is an antineoplastic antibiotic that acts as an alkylating agent by inhibiting DNA and protein synthesis. It can inhibit cell division, protein synthesis, and fibroblast proliferation. Topical application of mitomycin-C (0.4 mg/mL) was used as an adjuvant treatment in the endoscopic laser management of laryngeal and tracheal stenosis in 15 patients. Fourteen patients (93%) have shown improvement of their airway and resolution of their preoperative symptoms. After a mean follow-up of 18 months, no complication was noted with regard to the application of mitomycin-C. This study gives promising findings on the efficacy and safety of mitomycin-C as an adjuvant treatment in the management of selected cases of laryngeal and tracheal stenosis.
详细资料
- 关键词: Administration, Topical; Adolescent; Adult; Aged; Antimetabolites/*administration & dosage/adverse effects; Child; Child, Preschool; Cicatrix/prevention & control; Combined Modality Therapy; Female; Humans; Intraoperative Period; Laryngoscopy; Laryngostenosis/*surgery; Laser Therapy; Male; Middle Aged; Mitomycin/*administration & dosage/adverse effects; Nucleic Acid Synthesis Inhibitors/*administration & dosage/adverse effects; Prospective Studies; Recurrence; Tracheal Stenosis/*
- 文献种类: Multicenter Study
- 期刊名称: The Annals of Otology, Rhinology, and Laryngology
- 期刊缩写: Ann Otol Rhinol Laryngol
- 期卷页: 2001年第110卷第1期 1-6页
- 地址: Department of Otolaryngology and Communication Disorders, The Children's Hospital, Boston, Massachusetts 02115, USA
- ISBN: 0003-4894
- 备注:PMID:11201800
学科领域生物医药 » 临床医学
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丝裂霉素C
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