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Randomized clinical trial of the effect of postoperative intravenous fluid restriction on recovery after elective colorectal surgery

独南行添加于 2010-8-24 23:23 | 700 次阅读 | 0 个评论

作者
MacKay G, Fearon K, McConnachie A, Serpell MG, Molloy RG, O'Dwyer PJ
摘要
BACKGROUND: Use of intravenous fluids is an important part of perioperative management. The aim of this study was to compare outcome following administration of restricted or standard postoperative intravenous fluids and sodium in patients undergoing elective colorectal surgery. METHODS: Eighty patients were randomized to restricted fluids (less than 2 litres water and 77 mmol sodium for 24 h after surgery) or a standard postoperative fluid regimen (3 litres water and 154 mmol sodium per day for as long as necessary). The primary endpoint was hospital stay. RESULTS: The median (i.q.r.) total intravenous fluid intake in the restricted group was 4.50 (4.00-5.62) litres compared with 8.75 (8.00-9.80) litres in the standard group (P < 0.001). Intravenous sodium intake was also significantly less in the restricted group (229 (131-332) versus 560 (477-667) mmol; P < 0.001). There was no difference in median time to first flatus (2.9 versus 2.9 days; hazard ratio (HR) 0.85 (95 per cent confidence interval (c.i.) 0.54 to 1.32); P = 0.466) or first bowel motion (4.7 versus 4.9 days; HR 1.06 (95 per cent c.i. 0.68 to 1.65); P = 0.802) between the restricted and standard groups, or in median hospital stay (7.2 versus 7.2 days; HR 1.03 (95 per cent c.i. 0.66 to 1.61); P = 0.902). CONCLUSION: Restriction of postoperative intravenous fluid and sodium does not reduce hospital stay following elective colorectal surgery.
详细资料
- 关键词: Aged; Aged, 80 and over; *Colorectal Surgery; Female; Fluid Therapy/*methods; Humans; Infusions, Intravenous; Length of Stay; Male; Postoperative Care/*methods; Postoperative Complications/prevention & control; *Surgical Procedures, Elective; Treatment Outcome
- 文献种类: Randomized Controlled Trial
- 期刊名称: The British Journal of Surgery
- 期刊缩写: Br J Surg
- 期卷页: 2006年第93卷第12期 1469-1474页
- 地址: University Department of Surgery, Gartnavel General Hospital, Glasgow, UK. drgjmac@hotmail.com
- ISBN: 0007-1323
- 备注:PMID:17078116
学科领域生物医药 » 临床医学
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