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Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds

唐唐添加于 2012-2-29 21:09 | 2114 次阅读 | 0 个评论

作者
Grandjean P, Andersen EW, Budtz-Jorgensen E, Nielsen F, Molbak K, Weihe P, Heilmann C
摘要
Context Perfluorinated compounds (PFCs) have emerged as important food contaminants. They cause immune suppression in a rodent modelat serum concentrations similar to those occurring in the US population, but adverse health effects of PFC exposure are poorlyunderstood.Objective To determine whether PFC exposure is associated with antibody response to childhood vaccinations.Design, Setting, and Participants Prospective study of a birth cohort from the National Hospital in the Faroe Islands. A total of 656 consecutive singletonbirths were recruited during 1997-2000, and 587 participated in follow-up through 2008.Main Outcome Measures Serum antibody concentrations against tetanus and diphtheria toxoids at ages 5 and 7 years.Results Similar to results of prior studies in the United States, the PFCs with the highest serum concentrations were perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Among PFCs in maternal pregnancy serum, PFOS showed the strongestnegative correlations with antibody concentrations at age 5 years, for which a 2-fold greater concentration of exposure wasassociated with a difference of ?39% (95% CI, ?55% to ?17%) in the diphtheria antibody concentration. PFCs in the child'sserum at age 5 years showed uniformly negative associations with antibody levels, especially at age 7 years, except that thetetanus antibody level following PFOS exposure was not statistically significant. In a structural equation model, a 2-foldgreater concentration of major PFCs in child serum was associated with a difference of ?49% (95% CI, ?67% to ?23%) in theoverall antibody concentration. A 2-fold increase in PFOS and PFOA concentrations at age 5 years was associated with oddsratios between 2.38 (95% CI, 0.89 to 6.35) and 4.20 (95% CI, 1.54 to 11.44) for falling below a clinically protective levelof 0.1 IU/mL for tetanus and diphtheria antibodies at age 7 years.Conclusion Elevated exposures to PFCs were associated with reduced humoral immune response to routine childhood immunizations in childrenaged 5 and 7 years.
详细资料
- 文献种类: Journal Article
- 期刊名称: JAMA: The Journal of the American Medical Association
- 期刊缩写: JAMA: The Journal of the American Medical Association
- 期卷页: 2012年第307卷第4期 391-397页
- ISBN: 0098-7484
学科领域工程技术 » 管理学
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食品包装或能影响儿童疫苗效果

《美国医学会杂志》(JAMA)刊登的一项研究结果表明，过度摄入一种广泛应用于食品包装的化合物可能会导致例行儿童接种疫苗效力降低。

研究人员对656名1999年及2000年在法罗群岛国立医院出生的儿童进行了追踪调查，调查时间从出生持续至2008年。法罗群岛是丹麦的自治领地，位于冰岛和苏格兰之间。

在几个重要年龄点，研究人员测量了母亲和孩子体内全氟化合物（PFC）的含量，这是一组用于包括食品包装在内的一系列工业应用的化学品。之前已有研究表明全氟化合物与啮齿类动物免疫力下降有关。

这些孩子五岁时接受了例行破伤风和白喉疫苗接种。五岁时人体最常见的全氟化合物在血液中的含量越高，接种的免疫反应越弱，因此疫苗失效的风险就越大。例如其中一种全氟化合物全氟辛酸，若儿童五岁时体内全氟辛酸浓度增加两倍，白喉疫苗接种抗体反应降至“临床保护性”界限以下的风险就会增加一倍以上。

值得注意的是，尚不清楚研究结果是否适用于世界其他人口。有证据表明法罗群岛居民可能通过他们的食物摄入了更多的全氟化合物，其中包括鲸鱼肉。（来源：《华尔街日报》中文版）

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Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds

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