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Clinicopathological and prognostic significance of EGFR over-expression in esophageal squamous cell carcinoma: a meta-analysis

karmarks 添加于 2012-9-28 10:05 | 1236 次阅读 | 0 个评论

作者
Yu W-W, Guo Y-M, Zhu M, Cai X-W, Zhu Z-F, Zhao W-X, Fu X-L
摘要
BACKGROUND/AIMS: To elucidate the clinicopathological and prognostic significance of epidermal growth factor receptor (EGFR) over-expression in esophageal squamous cell carcinoma (ESCC). METHODOLOGY: A meta-analysis of previous studies was performed to assess the effects of EGFR over-expression on clinicopathological parameters and overall survival (OS) in patients with ESCC, using pooled odds ratio (OR) with its 95% confidence interval (CI) and pooled hazard ratio (HR) with its 95% CI, respectively. RESULTS: A total of nine studies including 802 patients were subjected to the final analysis. The overall results suggested that over-expression of EGFR was significantly correlated with, not only the lymph node status and tumour differentiation grade, with a pooled OR of 0.64 (95% CI: 0.46-0.89; Z=2.62; p=0.009) and 1.60 (95% CI: 1.09-2.37; Z=2.37; p=0.018), respectively, but also the poorer OS with a pooled HR of 1.60 (95% CI: 1.05-2.43; Z=2.19 p=0.028). CONCLUSIONS: This meta-analysis suggests that over-expression of EGFR might play an important role in the progression of ESCC, and it might be useful as a predictive biomarker in clinical practice, yet the predictive value of EGFR in ESCC still needs further confirmation by prospective trials.
详细资料
- 关键词: Carcinoma, Squamous Cell/chemistry/mortality/*pathology; Confidence Intervals; Esophageal Neoplasms/chemistry/mortality/*pathology; Humans; Odds Ratio; Prognosis; Receptor, Epidermal Growth Factor/*analysis
- 文献种类: Meta-Analysis
- 期刊名称: Hepato-Gastroenterology
- 期刊缩写: Hepatogastroenterology
- 期卷页: 2011年第58卷第106期 426-431页
- 地址: Department of Radiation Oncology, Fudan University Cancer Hospital, Fudan University, Shanghai, China
- ISBN: 0172-6390
学科领域生物医药 » 预防卫生学
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