新科学想法 › 学术文库 › 学术文献 › 浏览文献

Expression of human epidermal growth factor and its receptor in esophageal cancer

karmarks 添加于 2012-9-28 10:22 | 1107 次阅读 | 0 个评论

作者
Mukaida H, Yamamoto T, Hirai T, Toi M, Nakamura T, Wada T, Yamashita Y, Kawano K, Niimoto M
摘要
The expression of human epidermal growth factor (hEGF) was examined immunohistochemically in 86 esophageal cancer lesions, comprising 67 primary tumors and 19 metastatic lymph nodes. In the normal esophagus, the parabasal and intermediate cell layers showed a weak expression of hEGF, however, hEGF-positive tumor cells were detected in 62 (92.5 per cent) of the 67 primary esophageal carcinomas and in 18 (94.7 per cent) of the 19 metastatic lymph nodes. In this study, the immunoreactivity of hEGF was classified into 4 grades according to the number of stained tumor cells. A significant correlation was observed between the histologic type and the grade of hEGF immunoreactivity (Chi-square test, p less than 0.01). hEGF immunoreactivity in well differentiated squamous cell carcinomas was significantly higher than in other squamous cell carcinomas, although there were no correlations between other pathological findings and hEGF immunoreactivity. Patients with hEGF immunoreactivities of grades II or III had much worse prognoses than those with grades 0 or I (p less than 0.05). In 22 esophageal carcinomas and 10 normal esophageal mucosae, EGF receptor (EGFR) contents were measured by the competitive binding assay. The average EGFR content (101.3 +/- 35.7 fmol/mg protein, mean +/- SE) of the esophageal carcinomas was significantly higher than that (5.3 +/- 1.2) of the normal esophageal mucosae (p less than 0.05). Moreover, in hEGF negative tumors, EGFR contents were lower than in hEGF positive tumors. These results suggest that hEGF and EGFR show increased production in squamous cell carcinomas and could to be useful prognostic factors in patients with esophageal cancer.
详细资料
- 关键词: Carcinoma, Squamous Cell/*metabolism/mortality; Epidermal Growth Factor/*analysis; Esophageal Neoplasms/*metabolism/mortality; Humans; Immunoenzyme Techniques; Receptor, Epidermal Growth Factor/*analysis; Survival Rate
- 文献种类: Journal Article
- 期刊名称: The Japanese Journal of Surgery
- 期刊缩写: Jpn J Surg
- 期卷页: 1990年第20卷第3期 275-282页
- 地址: Department of Surgery, Hiroshima University, Japan
- ISBN: 0047-1909
学科领域生物医药 » 预防卫生学
相关链接 URL
karmarks 的文献笔记订阅