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Genetic evolution of the neuraminidase of influenza A (H3N2) viruses from 1968 to 2009 and its correspondence to haemagglutinin evolution

icecream 添加于 2012-10-11 21:03 | 951 次阅读 | 0 个评论

作者
Westgeest KB, de Graaf M, Fourment M, Bestebroer TM, van Beek R, Spronken MIJ, de Jong JC, Rimmelzwaan GF, Russell CA, Osterhaus ADME, Smith GJD, Smith DJ, Fouchier RAM
摘要
Each year, influenza viruses cause epidemics by evading pre-existing humoral immunity through mutations in the major glycoproteins: the haemagglutinin (HA) and the neuraminidase (NA). In 2004, the antigenic evolution of HA of human influenza A (H3N2) viruses was mapped (Smith et al., Science 305, 371-376, 2004) from its introduction in humans in 1968 until 2003. The current study focused on the genetic evolution of NA and compared it with HA using the dataset of Smith and colleagues, updated to the epidemic of the 2009/2010 season. Phylogenetic trees and genetic maps were constructed to visualize the genetic evolution of NA and HA. The results revealed multiple reassortment events over the years. Overall rates of evolutionary change were lower for NA than for HA1 at the nucleotide level. Selection pressures were estimated, revealing an abundance of negatively selected sites and sparse positively selected sites. The differences found between the evolution of NA and HA1 warrant further analysis of the evolution of NA at the phenotypic level, as has been done previously for HA.
详细资料
- 文献种类: Journal Article
- 期刊名称: The Journal of General Virology
- 期刊缩写: J Gen Virol
- 期卷页: 2012年第93卷第Pt 9期 1996-2007页
- 地址: Department of Virology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands
- ISBN: 0022-1317
学科领域生物医药 » 预防卫生学
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