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Mapping of H3N2 influenza antigenic evolution in China reveals a strategy for vaccine strain recommendation

icecream 添加于 2012-10-11 21:17 | 998 次阅读 | 0 个评论

作者
Du X, Dong L, Lan Y, Peng Y, Wu A, Zhang Y, Huang W, Wang D, Wang M, Guo Y, Shu Y, Jiang T
摘要
One of the primary efforts in influenza vaccine strain recommendation is to monitor through gene sequencing the viral surface protein haemagglutinin (HA) variants that lead to viral antigenic changes. Here we have developed a computational method, denoted as PREDAC, to predict antigenic clusters of influenza A (H3N2) viruses with high accuracy from viral HA sequences. Application of PREDAC to large-scale HA sequence data of H3N2 viruses isolated from diverse regions of Mainland China identified 17 antigenic clusters that have dominated for at least one season between 1968 and 2010. By tracking the dynamics of the dominant antigenic clusters, we not only find that dominant antigenic clusters change more frequently in China than in the United States/Europe, but also characterize the antigenic patterns of seasonal H3N2 viruses within China. Furthermore, we demonstrate that the coupling of large-scale HA sequencing with PREDAC can significantly improve vaccine strain recommendation for China.
详细资料
- 关键词: Antigenic Variation; Antigens, Viral/*genetics/*immunology; Base Sequence; China; Computer Simulation; Drug Design; *Evolution, Molecular; Genetic Variation; Hemagglutinin Glycoproteins, Influenza Virus/*genetics/*immunology; Humans; Influenza A Virus, H3N2 Subtype/genetics/*immunology/isolation & purification; Influenza, Human/virology; Models, Immunological; Phylogeny; Sequence Analysis, DNA
- 文献种类: Journal Article
- 期刊名称: Nature Communications
- 期刊缩写: Nat Commun
- 期卷页: 2012年第3卷 709页
- 地址: Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
- ISBN: 2041-1723
学科领域生物医药 » 预防卫生学
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