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MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma

icecream 添加于 2012-10-14 23:28 | 1089 次阅读 | 0 个评论

作者
Xu X, Chen Z, Zhao X, Wang J, Ding D, Wang Z, Tan F, Tan X, Zhou F, Sun J, Sun N, Gao Y, Shao K, Li N, Qiu B, He J
摘要
MicroRNAs (miRNAs) as a species of small non coding single stranded RNA of about 21-25 nucleotides have important roles in the development of different cancers. In present study, we found that the expression of miR-25 was up-regulated in 60 esophageal squamous cell carcinoma (ESCC) tissues compared with matched adjacent non-cancer tissues. Moreover, we demonstrated that the up-regulation of miR-25 was significantly correlated with the status of lymph node metastasis and TNM (Tumor, Node and Metastasis) stage. Furthermore, over-expression of miR-25 markedly promoted migration and invasion of ESCC cells. On the contrary, down-regulation of miR-25 inhibited the migration and invasion of cells. E-cadherin(CDH1) is a very important tumor metastasis suppressor. We further identified that miR-25 directly targeted CDH1 3'-untranslated region (3'UTR) and repressed the expression of CDH1. These results, for the first time, demonstrate that miR-25 promotes ESCC cell migration and invasion by suppressing CDH1 expression.
详细资料
- 关键词: 3' Untranslated Regions/genetics; Cadherins/genetics; Carcinoma, Squamous Cell/genetics/metabolism/*pathology; Cell Line, Tumor; *Cell Movement; Esophageal Neoplasms/genetics/metabolism/*pathology; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs/genetics/*metabolism; Neoplasm Invasiveness; Neoplasm Staging
- 文献种类: Journal Article
- 期刊名称: Biochemical and Biophysical Research Communications
- 期刊缩写: Biochem Biophys Res Commun
- 期卷页: 2012年第421卷第4期 640-645页
- 地址: Department of Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
- ISBN: 0006-291X
学科领域生物医药 » 预防卫生学
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