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PLC-epsilon1 Gene Polymorphisms Significantly Enhance the Risk of Esophageal Squamous Cell Carcinoma in Individuals with a Family History of Upper Gastrointestinal Cancers

icecream 添加于 2012-10-21 21:33 | 1022 次阅读 | 0 个评论

作者
Zhou R-M, Li Y, Wang N, Liu B-C, Chen Z-F, Zuo L-F
摘要
BACKGROUND AND AIMS: Phospholipase C epsilon 1 (PLCepsilon1) may regulate cell growth, differentiation, apoptosis and angiogenesis and play an important role in carcinogenesis and the progression of several cancers. This study was designed to validate the association of the PLCepsilon1 rs2274223 single nucleotide polymorphism (SNP) with esophageal squamous cell carcinoma (ESCC) as identified by genome-wide association studies (GWAS) and further assess whether the rs11599672 SNP could affect an individual's susceptibility to ESCC. METHODS: These two SNPs were genotyped by polymerase chain reaction ligase detection reaction (PCR-LDR) in 527 ESCC patients and 527 controls. RESULTS: Compared with the rs2274223 SNP AA genotype, other genotypes or combined genotypes all enhanced the risk of ESCC. Further analyses showed that AG/GG genotype carriers with a family history of upper gastrointestinal cancers (UGIC) had an increased risk of ESCC than those AA genotype carriers without UGIC family history (OR = 2.10, 95% CI = 1.46-3.10). Overall, rs11599672 SNP had no influence on ESCC susceptibility. However, UGIC family history elevated the risk of ESCC for subjects with the TT genotype (OR = 1.59, 95% CI = 1.13-2.24). CONCLUSIONS: These results highlighted the role of a genetic factor in ESCC and suggested that the PLCepsilon1 rs2274223 SNP might be an effective genetic marker to assess the risk of ESCC in individuals with a UGIC family history from a region of high incidence in northern China.
详细资料
- 文献种类: Journal Article
- 期刊名称: Archives of Medical Research
- 期刊缩写: Arch Med Res
- 期卷页: 2012年
- 地址: Department of Molecular Biology, The Fourth Affiliated Hospital of Hebei Medical University, Hebei Province, China
- ISBN: 0188-4409
学科领域生物医药 » 预防卫生学
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