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Survivin--prognostic tumor biomarker in human neoplasms--review

icecream 添加于 2012-11-8 21:45 | 1078 次阅读 | 0 个评论

作者
Waligorska-Stachura J, Jankowska A, Wasko R, Liebert W, Biczysko M, Czarnywojtek A, Baszko-Blaszyk D, Shimek V, Ruchala M
摘要
Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers is carried out in order to quickly identify tumor cells and predict treatment response, ultimately leading to a favorable therapeutic outcome. One such prognostic marker seems to be survivin. Many studies have shown that survivin is strongly expressed in a vast majority of cancers. Its overexpression was demonstrated in breast and lung cancer prostate, gastric, colon, bladder and esophageal carcinomas, osteosarcomas, and lymphomas. In many of those tumors, high activity of the surviving gene was associated with a poor prognosis and worse survival rates. Moreover survivin expression was correlated with resistance to chemotherapy and radiotherapy-induced apoptosis. Since survivin may be identified as an independent prognostic factor and inhibitor of apoptosis, it may prove to be a useful therapeutic target in cancer therapy
详细资料
- 关键词: Apoptosis; Disease Progression; Humans; Inhibitor of Apoptosis Proteins/*metabolism; Neoplasm Staging; Neoplasms/diagnosis/*metabolism/pathology; Prognosis; Tumor Markers, Biological/*metabolism
- 文献种类: Journal Article
- 期刊名称: Ginekologia Polska
- 期刊缩写: Ginekol Pol
- 期卷页: 2012年第83卷第7期 537-540页
- 地址: Deparment of Endocrinology, Metabolism and Intemnal Diseases, University of Medical Sciences in Poznan, Poland. joanna.stachura@gmail.com
- ISBN: 0017-0011
学科领域生物医药 » 预防卫生学
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