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MicroRNAs in esophageal cancer (review)

icecream 添加于 2012-11-8 21:59 | 1054 次阅读 | 0 个评论

作者
He B, Yin B, Wang B, Xia Z, Chen C, Tang J
摘要
Esophageal cancer (EC) is one of the most common malignant tumors worldwide. EC is usually diagnosed at a locally advanced stage or at a stage with involvement of lymph nodes. Despite aggressive treatment, the overall five-year survival rate remains poor. microRNAs (miRNAs) are small, non-coding endogenous RNAs that negatively regulate gene expression at the post-transcriptional and/or translational level. Accumulating evidence suggests that the deregulation of miRNAs not only results in cancer progression, but also directly promotes tumor initiation. Previous studies found that miRNAs are frequently deregulated in EC, indicating that miRNAs are important in tumorigenesis. In this review, we summarize therecently recognized miRNA expression and its impact on the biology of EC and the potential applications for EC.
详细资料
- 关键词: Biological Markers/metabolism; Epigenesis, Genetic; Esophageal Neoplasms/genetics/*metabolism/pathology; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs/*metabolism; Neoplasm Invasiveness; Polymorphism, Single Nucleotide; Prognosis
- 文献种类: Journal Article
- 期刊名称: Molecular Medicine Reports
- 期刊缩写: Mol Med Report
- 期卷页: 2012年第6卷第3期 459-465页
- 地址: Department of Cardiothoracic Surgery, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China
- ISBN: 1791-2997
学科领域生物医药 » 预防卫生学
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