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NBS1 8360G > C polymorphism is associated with breast cancer risk: a meta-analysis

icecream 添加于 2012-12-2 10:50 | 1202 次阅读 | 0 个评论

作者
Wang Z, Cui D, Lu W
摘要
NBS1 gene plays an important role in DNA repair. Many epidemiological studies have investigated the association between NBS1 8360G > C polymorphism and breast cancer, however, the results are still controversial. Therefore, we performed a meta-analysis of 10 case-control studies. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. The results showed NBS1 8360G > C polymorphism contributed to breast risk in overall populations (for CC vs. GG: OR = 0.75, 95% CI = 0.74-0.98, P = 0.13 for heterogeneity; for the recessive model CC vs. GG/CG: OR = 0.88, 95% CI = 0.77-1.00, P = 0.44 for heterogeneity). In subgroup analysis by ethnicity, no significant association was found in all genetic models. In summary, our meta-analysis strongly suggests the NBS1 8360G > C polymorphism is associated with breast cancer.
详细资料
- 关键词: Breast Neoplasms/ethnology/*genetics; Case-Control Studies; Cell Cycle Proteins/*genetics; Continental Population Groups/genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Linear Models; Nuclear Proteins/*genetics; Odds Ratio; Phenotype; *Polymorphism, Genetic; Risk Assessment; Risk Factors
- 文献种类: Meta-Analysis
- 期刊名称: Breast Cancer Research and Treatment
- 期刊缩写: Breast Cancer Res Treat
- 期卷页: 2010年第123卷第2期 557-561页
- 地址: Department of Epidemiology and Biostatistics, Nanjing Medical University, 210029, Nanjing, China
- ISBN: 0167-6806
学科领域生物医药 » 预防卫生学
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