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[Psychoneuroimmunology: an update]

哈o哈o 添加于 2010-3-19 10:10 | 1004 次阅读 | 0 个评论

作者
Schubert C, Schussler G
摘要
Psychoneuroimmunology (PNI) is closely associated with the bidirectional pathways between mind/brain and the immune system. PNI research represents a rapidly growing area within psychosomatic research. Recent studies in PNI are based mainly on the immunological concepts of Th1/Th2 dichotomy and inflammation. This review covers human PNI studies dealing with stress-associated changes in cytokine (Th1, Th2) levels in immune-related processes such as wound healing, atopic diseases as well as autoimmune and other inflammatory diseases. It is shown that PNI studies measuring immune activity near the site of the disease (e. g. woundhealing) and dealing with objective stressors show more consistent findings (stress-associated Th1/Th2 shift, stress-associated proinflammatory activation) than those dealing with chronic and complex diseases (e. g., autoimmune disease). This warrants the expansion of the methodological repertoire in future PNI research toward designs allowing for the investigation of complex psychosomatic phenomena.
详细资料
- 关键词: Arousal/physiology; Autoimmune Diseases/*immunology/psychology; Cytokines/blood; Humans; Hypersensitivity/*immunology/psychology; Illness Behavior; Inflammation/*immunology/psychology; *Psychoneuroimmunology; Psychophysiologic Disorders/*immunology/psychology; Risk Factors; Stress, Psychological/complications/*immunology; Th1 Cells/immunology; Th2 Cells/immunology
- 文献种类: Journal Article
- 期刊名称: Zeitschrift fur Psychosomatische Medizin und Psychotherapie
- 期刊缩写: Z Psychosom Med Psychother
- 期卷页: 2009年第55卷第1期 3-26页
- 地址: Universitatsklinik fur Medizinische Psychologie, Medizinische Universitat Innsbruck, Schopfstr. 23a, A-6020 Innsbruck. christian.schubert@i-med.ac.at
- ISBN: 1438-3608
- 备注:PMID:19353509
学科领域生物医药 » 临床医学
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