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Mechanisms of age-related macular degeneration

yucloud 添加于 2012-8-10 16:06 | 1103 次阅读 | 0 个评论

作者
Ambati J, Fowler BJ
摘要
Age-related macular degeneration (AMD), a progressive condition that is untreatable in up to 90% of patients, is a leading cause of blindness in the elderly worldwide. The two forms of AMD, wet and dry, are classified based on the presence or absence of blood vessels that have disruptively invaded the retina, respectively. A detailed understanding of the molecular mechanisms underlying wet AMD has led to several robust FDA-approved therapies. In contrast, there are no approved treatments for dry AMD. In this review, we provide insight into the critical effector pathways mediating each form of the disease. A recurring theme that spans most aspects of AMD pathogenesis is defective immune modulation in the classically immune-privileged ocular haven. Interestingly, the latest advances in AMD research also highlight common molecular disease pathways with other neurodegenerative disorders. Finally, the therapeutic potential of intervening at known mechanistic steps of AMD pathogenesis is discussed.
详细资料
- 文献种类: Journal Article
- 期刊名称: Neuron
- 期刊缩写: Neuron
- 期卷页: 2012年第75卷第1期 26-39页
- 地址: Department of Ophthalmology & Visual Sciences, University of Kentucky, Lexington, KY 40506, USA; Department of Physiology, University of Kentucky, Lexington, KY 40506, USA
- ISBN: 0896-6273
学科领域生物医药 » 药学
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