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miR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1

Slash 添加于 2013-2-16 17:18 | 1052 次阅读 | 0 个评论

作者
Takeshita N, Mori M, Kano M, Hoshino I, Akutsu Y, Hanari N, Yoneyama Y, Ikeda N, Isozaki Y, Maruyama T, Akanuma N, Miyazawa Y, Matsubara H
摘要
The expression of microRNA-203 (miR-203) in esophageal squamous cell carcinoma (ESCC) tissues is remarkably lower than that in nonESCC tissues. We investigated how miR-203 could influence the development of ESCC cells. Our analyses revealed that miR-203 inhibited the migration and invasion of ESCC cells. Genome-wide gene expression data and target site inhibition assays showed that miR-203 appears to directly regulate LIM and SH3 protein 1 (LASP1). The knockdown of LASP1 resulted in inhibition of the migration and invasion of ESCC cells. Our results suggest that miR-203 and its target LASP1, may be associated with the progression of ESCC. In clinical ESCC specimens, the expression levels of miR-203, which were lower compared to those in normal tissues, were inversely correlated with the mRNA expression levels of LASP1. Moreover, we found that there was a significant correlation between the expression levels of miR-203 and the relapsefree survival. The identification of a cancer network regulated by miR-203 could provide new insights into the potential mechanisms of the progression of ESCC.
详细资料
- 文献种类: Journal Article
- 期刊名称: International Journal of Oncology
- 期刊缩写: Int J Oncol
- 期卷页: 2012年第41卷第5期 1653-1661页
- 地址: Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
- ISBN: 1019-6439
学科领域生物医药 » 药学
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