https://www.xinkexue.com/ 新科学想法 新科学想法 新科学文献管理系统 1970-1-1 08:00 https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33524 https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33524#comments 标题：Bloom Filter A Data Structure for Computer Networking, Big Data, Cloud Computing, Internet of Things, Bioinformatics and Beyond
作者：Ripon Patgiri,Sabuzima Nayak,Naresh Muppalaneni
文献笔记：<h1 data-testid="title" style="box-sizing: border-box; margin: 0px 0px 0.373rem; padding: 0px; vertical-align: baseline; color: rgb(34, 34, 34); line-height: 3rem; text-rendering: optimizelegibility; font-size: 2.25rem; max-width: inherit; font-family: elsevierdisplaylight, arial, sans-serif; font-feature-settings: &quot;kern&quot;, &quot;liga&quot;, &quot;pnum&quot; 0, &quot;tnum&quot;, &quot;onu ... ]]> 文献管理 Thu, 02 Dec 2021 12:45:14 GMT https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33351 https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33351#comments 标题：A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling
作者：Qian J,Olbrecht S,Boeckx B,Vos H,Laoui D,Etlioglu E,Wauters E,Pomella V,Verbandt S,Busschaert P,Bassez A,Franken A,Bempt MV,Xiong J,Weynand B,van Herck Y,Antoranz A,Bosisio FM,Thienpont B,Floris G,Vergote I,Smeets A,Tejpar S,Lambrechts D
来源：Cell Research 全文链接: DOI URL
文献笔记：欢迎指教 ]]> 文献管理 Mon, 06 Jul 2020 00:04:38 GMT https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33344 https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33344#comments 作者：Calderon, A.P.
来源：ATAS of SBM (Rio de Janeiro) 
文献笔记：This article originally published at the “ Seminar on Numerical Analysis and its Application to Continuum Physics” in the ATAS of SBM (Rio de Janeiro), 1980, pp. 65– 73. ]]> 文献管理 Wed, 03 Jun 2020 09:55:15 GMT https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33289 https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33289#comments 作者：Matthews HK,Ganguli S,Plak K,Taubenberger AV,Win Z,Williamson M,Piel M,Guck J,Baum B
来源：Developmental Cell 全文链接: DOI URL
文献笔记：RAS让狭窄空间中的肿瘤更好的分裂，包膜更坚固，保证有丝分裂时形状还是圆的，这就让细胞分裂出错的几率减少。<div>RAS 改善genome stability的这种悖论就非常有意思了，其他癌基因说不能也可以做到！</div> ]]> 文献管理 Thu, 06 Feb 2020 16:50:09 GMT https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33287 https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33287#comments 标题：An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates
作者：Goveia J,Rohlenova K,Taverna F,Treps L,Conradi L-C,Pircher A,Geldhof V,de Rooij LPMH,Kalucka J,Sokol L,Garcia-Caballero M,Zheng Y,Qian J,Teuwen L-A,Khan S,Boeckx B,Wauters E,Decaluwe H,De Leyn P,Vansteenkiste J,Weynand B,Sagaert X,Verbeken E,Wolthuis A,Topal B,Everaert W,Bohnenberger H,Emmert A,Panovska D,De Smet F,Staal FJT,Mclaughlin RJ,Impens F,Lagani V,Vinckier S,Mazzone M,Schoonjans L,Dewerchin M,Eelen G,Karakach TK,Yang H,Wang J,Bolund L,Lin L,Thienpont B,Li X,Lambrechts D,Luo Y,Carmeliet P
摘要：Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell level. We single-cell RNA (scRNA)-sequenced 56,771 endothelial cells from human/mouse (peri)-tumoral lung and cultured hum ......
来源：Cancer Cell 全文链接: DOI URL
文献笔记：迄今为止对肺内皮细胞最完备的描述！<div>想想也许对最近的2009冠状病毒研究也帮助<br><div><br></div></div> ]]> 文献管理 Tue, 28 Jan 2020 14:19:19 GMT https://www.xinkexue.com/home.php?mod=space&uid=1&do=blog&id=6121 https://www.xinkexue.com/home.php?mod=space&uid=1&do=blog&id=6121#comments 个人日志 Mon, 30 Dec 2019 14:37:28 GMT https://www.xinkexue.com/home.php?mod=space&uid=1&do=blog&id=6120 https://www.xinkexue.com/home.php?mod=space&uid=1&do=blog&id=6120#comments 个人日志 Sat, 28 Dec 2019 22:14:00 GMT https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33280 https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33280#comments 作者：Dardé J,Hyvönen N,Seppänen A,Staboulis S
来源：Inverse Problems 全文链接: DOI URL
文献笔记：<div style="white-space: pre-wrap; text-align: left; line-height: 1.75; font-size: 14px;">电阻抗透视成像学的实用综述，并提出介质参数与形状同时优化的算法，形状模型对反演结果的显著影响，在同时优化形状与性质参数时，结果更接近真实，不过会部分牺牲异质物形状。建议实用成像需要考虑到电极与被测边界的接触电阻干扰。</div> ... ]]> 文献管理 Mon, 16 Dec 2019 03:46:59 GMT https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33279 https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33279#comments 标题：Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation
作者：Roy B,Verma V,Sim J,Fontan A,Joglekar AP
来源：The Journal of Cell Biology 全文链接: DOI URL
文献笔记：这个问题其实之前有过研究，PP1不能太早处于活跃状态，否则联会就出问题，<div>之前研究的SDS22的敲除实验就是可以增加联会速度的，已经能说明问题了。</div><div>这个领域玄乎的地方在于PP1是不是主动被传送到kinetochore的，一些马达蛋白可能有贡献，但是如何观察这种传输与卸货的过程呢？</div> ... ]]> 文献管理 Tue, 29 Oct 2019 08:44:22 GMT https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33278 https://www.xinkexue.com/bib.php?mod=ref&do=view&refid=33278#comments 标题：Quantitative Spatial Profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 Predicts Improved Outcomes of anti-PD-1 Therapies in Metastatic Melanoma
作者：Johnson DB,Bordeaux JM,Kim J-Y,Vaupel CA,Rimm DL,Ho TH,Joseph RW,Daud AI,Conry RM,Gaughan EM,Hernandez-Aya LF,Dimou A,Funchain P,Smithy JW,Witte JS,McKee SB,Ko J,Wrangle J,Dabbas B,Tangri S,Lameh J,Hall JM,Markowitz J,Balko JM,Dakappagari NK
来源：Clinical Cancer Research 全文链接: DOI URL
文献笔记：喜欢该文的理念，那是一组生理现象。<div>空间上的一对（肿瘤细胞和与之接触的T细胞），也是interferon信号上的一对（HLA-DR / IDO1)</div><div>以后如果有可能，把这些对子都组起来形成一个网络，绝对更有价值<br><div><br></div></div> ]]> 文献管理 Mon, 28 Oct 2019 21:09:11 GMT