新科学想法 › 文献管理 › 浏览文献

Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view

热1 阿平添加于 2009-5-22 01:35 | 4817 次阅读 | 2 个评论

作者
Kelly AE, Funabiki H
摘要
The directed movement of chromosomes during mitosis and meiosis relies on microtubule-mediated connections between spindle poles and kinetochores assembled on chromosomes. The molecular basis for the dynamic interaction between microtubules and kinetochores is just beginning to be unveiled. Here, focusing on the mitotic centromere kinase Aurora B, we review our current understanding of the signaling pathways that correct erroneous microtubule attachment at kinetochores. We evaluate several potential models that may explain how maloriented attachments are recognized and processed by the Aurora B pathway.
详细资料
- 关键词: Animals; Centromere/*metabolism; Kinetochores/*metabolism; Microtubules/*metabolism; Models, Biological; Protein-Serine-Threonine Kinases/*metabolism
- 文献种类:期刊
- 期刊名称: Current Opinion in Cell Biology
- 期刊缩写: Curr Opin Cell Biol
- 期卷页: 2009年第21卷第1期 51-58页
- 地址: The Rockefeller University, Laboratory of Chromosome and Cell Biology, 1230 York Avenue, New York, NY 10065, USA
- ISBN: 1879-0410
- 备注:PMID:19185479
标签

Aurora 有丝分裂
相关链接 DOI URL
附件
全文下载
阿平的文献笔记订阅

比较关心Aurora B