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Spindle Checkpoint Silencing: PP1 Tips the Balance

热4 阿平添加于 2011-11-8 21:58 | 6030 次阅读 | 7 个评论

作者
Lesage B, Qian J, Bollen M
摘要
The spindle checkpoint is a mitotic surveillance mechanism that delays anaphase until all sister chromatids are correctly attached to microtubules from opposite poles. Recent studies reveal that protein kinase Aurora B is a key regulator of spindle checkpoint activation whereas protein phosphatase PP1 antagonizes Aurora B and induces checkpoint silencing. Chromosome biorientation stretches the kinetochores and spatially separates centromeric Aurora B from its kinetochore substrates, comprising several PP1-interacting proteins (PIPs). The ensuing dephosphorylation of these PIPs creates docking sites for the bulk recruitment of PP1 to the kinetochores. We propose that this tension-induced targeting of PP1 triggers checkpoint silencing by the dephosphorylation of kinetochore and checkpoint components, including Aurora B substrates. In addition, PP1 also directly inactivates a kinetochore-associated pool of Aurora B and silences checkpoint signaling by opposing the centromeric targeting of Aurora B.
详细资料
- 文献种类:期刊
- 期刊名称: Current Biology
- 期刊缩写: Current Biology
- 期卷页: 2011年第21卷第21期 R898-R903页
- ISBN: 0960-9822
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细胞周期
标签

PP1 Aurora
相关链接 DOI URL
附件
Spindle Checkpoint Silencing: PP1 Tips the Balance