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Do chromatin loops provide epigenetic gene expression states?

阿平添加于 2010-7-8 04:36 | 2443 次阅读 | 0 个评论

作者
Deng W, Blobel GA
摘要
Control of gene expression involves the concerted action of multiple regulatory elements some of which can act over large genomic distances. Physical interaction among these elements can lead to looping of the chromatin fiber. Although posttranslational modifications of chromatin are thought to play a role in the conveyance of epigenetic information, it is largely unknown whether higher order chromatin organization such as looping contributes to epigenetic memory. A related unresolved question is whether chromatin loops are the cause or the effect of transcriptional regulation. Recent work on diverse organisms suggests a memory function for long-range chromatin interactions. It is proposed that higher order folding of the chromatin fiber can serve to maintain active and repressed states of gene expression.
详细资料
- 文献种类:期刊
- 期刊名称: Current Opinion in Genetics & Development
- 期刊缩写: Current Opinion in Genetics & Development
- 期卷页: 2010年
- ISBN: 0959437X
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Do chromatin loops provide epigenetic gene expression states?