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Overcoming inhibition in the spindle checkpoint

阿平添加于 2010-1-13 07:14 | 2621 次阅读 | 0 个评论

作者
Vanoosthuyse V, Hardwick KG
摘要
Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing.
详细资料
- 关键词: *Gene Expression Regulation, Fungal; Kinetochores/metabolism; Mitotic Spindle Apparatus/*metabolism; Models, Biological; Protein Phosphatase 1/metabolism; Signal Transduction; *Yeasts/enzymology/genetics
- 文献种类:期刊
- 期刊名称: Genes & Development
- 期刊缩写: Genes Dev
- 期卷页: 2009年第23卷第24期 2799-2805页
- 地址: Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom. vvanoost@staffmail.ed.ac.uk
- ISBN: 1549-5477
- 备注:PMID:20008930
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分子生物学 细胞周期
标签

checkpoint 有丝分裂 PP1
相关链接 DOI URL

checkpoint的问题，要有checkpoint的思维

好的科学家在于会提好的问题，好的问题才可能有好的研究成果，我们学习的大约就是这样一种提问的能力吧？

这篇文章的作者把目前 spindle assembly checkpoint的几个主要的未解之谜探讨了一下，特别对蛋白磷酸酶在此过程中的作用也作了分析，并提出了自己的构想，非常赞！

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