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Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly

热1 阿平添加于 2014-7-8 05:34 | 9859 次阅读 | 3 个评论

作者
Hori T, Shang W-H, Toyoda A, Misu S, Monma N, Ikeo K, Molina O, Vargiu G, Fujiyama A, Kimura H, Earnshaw W C, Fukagawa T
详细资料
- 文献种类: Journal Article
- 期刊名称: Developmental Cell
- 期刊缩写: Developmental Cell
- 期卷页: 2014年第29卷第6期 740-749页
- ISBN: 1534-5807
学科领域生物医药 » 生物学
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只字不提condensin，牛

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!reply! centromere 2014-7-25 12:31: As you know, this modification plays multiple roles in various biological processes, including chromosome condensation. Condensin II is a potent candidate for recognition of H4K20me1 at centromere, but we need further experiment to demonstrate your point.

!reply! 阿平 2014-7-29 06:07: centromere: As you know, this modification plays multiple roles in various biological processes, including chromosome condensation. Condensin II is a potent cand ...
I thought the evidence for the direct binding between Condensin II and H4K20me1 was convincing as it was published in a Nature paper several years ago.
And some of the phenotypes after disruption of H4K20me1 may be explained by the defect of condensin as it was required for the stiffness of centromere and coordination of kinetochore movement (Ribeiro,2009).
To some extend, I can understand your understatement of this matter, however, I am eager to see the development of your future story!

!reply! centromere 2014-7-29 10:51: Thank you for your comments. I agree with you that condensin2 may be a key mediator protein between H4K20me1 and kinetochore components. However, In Riveiro’ paper, depletion of SMC2 do not cause loss of CENP-H at kinetochore, which is different from our observation, implying the H4K20me1 nucleosome itself, or through other binding partners may contribute to maintain a functional centromere.